Transient receptor potential channel regulation by growth factors

Calcium (Ca2+) is one of the most universal secondary messengers, owing its success to immense concentration gradient across plasma membrane. Dysregulation Ca2+ homeostasis can result in severe cell dysfunction, thereby initiating several pathologies like tumorigenesis and fibrosis. Transient receptor potential (TRP) channels represent a superfamily Ca2+-permeable ion that convey diverse physical chemical stimuli into physiological signal. Their broad expression pattern gating promiscuity support their involvement cellular response an altering environment. Growth factors (GF) are essential biochemical messengers contribute these environmental changes. Since GF signaling, TRP channel or function could be valid strategy for exert effect onto target. In this review, comprehensive understanding current knowledge regarding activation and/or modulation by presented.